Nioxin System 4 Guide: Thicken Colored Hair Safely Ranked

An educational guide from the Beauty AMZ research team. No hard sell, just what you need to know.
Why colored hair thins differently
Chemical processing weakens the hair shaft. Breakage mimics thinning at the lengths. Scalp health still drives new growth. System 4 addresses both breakage and scalp.
The color-safe 3-step routine
Cleanse gently with the System 4 shampoo. Condition with the moisture-balanced formula. Apply the leave-in treatment to the scalp. The order matters for results.
Timing around color appointments
Wait 48 hours after coloring before starting. Pause the system the day of dyeing. Resume once color sets. This protects both color and scalp.
Boosting results for dyed hair
Deep condition weekly for chemical damage. Use heat protectant always. Get regular trims to remove split ends. Protein-moisture balance is key for processed hair.
Long-term maintenance plan
Continue the system as long as you want thickness. Many users maintain indefinitely. Reassess thinning stage yearly. Switch systems if your hair state changes.
Recommended Products
These are the products our research team rates highest in this category.

Best for: Colored hair with progressed thinning.
Nioxin System 4 Scalp Cleaning Shampoo and Therapy Conditioner Set
- System 4 shampoo plus conditioner
- For colored hair, progressed thinning
- Protects color while thickening
- Niacinamide and biotin enriched
Pros
- Color-safe thickening duo
- Large salon sizes
- Protects expensive dye jobs
Cons
- Highest price in this set
- Bundle may ship separately
- Heavy for fine colored hair

Best for: Dyed hair starting serious thickening care.
Nioxin Scalp and Hair Thickening System 4, Full Size
- Full 3-month System 4 kit
- 3 steps for colored, damaged hair
- Progressed thinning formula
- Strengthens while protecting color
Pros
- Complete colored-hair system
- Three-month supply
- Award-winning thinning care
Cons
- Daily routine commitment
- Upfront cost
- Mint tingle is strong

Best for: Salon-style stocking up at home.
Nioxin System 4 Shampoo and Conditioner Prepack with Pumps, 33.8 oz
- Liter duo with pumps included
- Best value for long-term users
- System 4 color-safe formulas
- Pumps make shower use easy
Pros
- Pumps included is convenient
- Lowest cost per ounce
- Lasts many months
Cons
- Very high upfront price
- Huge bottles need space
- Commitment to one system

Best for: Refilling the crucial step 3.
Nioxin System 4 Scalp and Hair Thickening Treatment, 6.8 oz
- Step 3 leave-in treatment
- For colored hair, progressed thinning
- Boosts density and refreshes scalp
- Generous 6.8 oz size
Pros
- Larger treatment bottle
- Key density step
- Color-safe formula
Cons
- Needs steps 1 and 2
- Strong tingle
- Pricey alone

Best for: Colored hair testing System 4 first.
Nioxin Scalp and Hair Thickening System 4, Trial Size
- One-month System 4 trial kit
- All 3 steps in travel sizes
- Test on colored hair first
- Low-risk entry to Nioxin
Pros
- Affordable trial
- Tests color safety
- Complete mini routine
Cons
- Small sizes run out fast
- Short trial shows little
- Daily use required
Ready to Choose?
See our top product picks for nioxin 4, or jump straight to the head-to-head comparison of the two most popular options.
The color-safe volumizing tradeoff
Color-treated fine hair faces the central volumizing dilemma: sulfates cleanse well enough for oily fine roots but fade color fast, while the gentlest color-safe cleansers may not cut through the oil that flattens volume. System 4 exists to resolve this exact tradeoff with a color-safe formula strong enough for scalp cleansing. The practical test is color longevity: if color fades noticeably faster after switching to a volumizer, the formula is too harsh regardless of its volume claims.
Wash frequency interacts with the tradeoff: color-treated hair benefits from fewer washes anyway, so the volumizer needs to deliver multi-day volume to justify its place. Our OGX Biotin Collagen comparison shows another thickening system for the tradeoff analysis.
Colored hair thinning: cause matters
Colored hair thins differently, and the cause decides the product. Chemical processing weakens the strand, so breakage-driven thinness is common: the hair breaks faster than it grows, and the ends thin while the scalp density stays normal. True scalp thinning with visible scalp needs the density approach. The assessment: full density at the roots with thin ends means breakage, which needs handling changes plus the system; visible scalp means follicle-level thinning.
System 4's three steps address the scalp environment, which helps both causes but cannot fix breakage alone. Pair the system with gentler handling: less heat, wider-tooth combing, and trims that remove the breaking ends. If breakage continues despite the system, the coloring frequency or formula may need professional reassessment rather than more product.
The clarifying reset for System 4 buildup
Thickening systems coat the strand to create volume, and coatings accumulate into the paradox where the volumizer flattens hair. The signs on System 4: roots that used to lift now lie flat despite the same routine, and the shampoo lathers less than it did initially. The monthly clarifying reset dissolves the polymer layers, but colored hair needs a color-safe clarifier to avoid the fading that harsh clarifiers cause.
Schedule the reset deliberately once a month, not as a rescue when volume has already died. The trial size in this guide suits the cautious tester, while the 33.8 oz prepack serves the committed. Do not clarify weekly on colored hair; the color cost exceeds the volume benefit. If volume does not return after the reset, the cause is likely the hair's condition rather than buildup.
Second-day volume on colored hair
Color-treated hair needs volume that survives without daily washing, since each wash fades color. The second-day routine: flip the head upside down and massage roots for thirty seconds to break up flattened oils, apply dry shampoo only at the roots, and finish with a cool dryer blast while upside down. This reactivates the System 4's root lift without another color-stripping wash.
Our biotin hair oil guide covers a topical support option, though oils and volume conflict, so apply any oil to the ends only. If day-two volume consistently fails, the system may be too heavy for the hair type rather than misapplied; fine colored hair sometimes needs the lightest volumizing tier, not the full system.